Titlebook: Genetics Meets Metabolomics; from Experiment to S Karsten Suhre Book 2012 Springer Science+Business Media, LLC 2012 Metabolomics.Systems Bi

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Metabolomic Systems Biology of Protozoan Parasites,gy on two major protozoan pathogens, the African trypanosome ., causative agent of sleeping sickness, and the . parasites responsible for visceral leishmaniasis, also known as kala-azar, on the Indian subcontinent.

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Metabolomics Applications in Human Nutrition,ntain not only endogenously produced metabolites but also the nutrients and metabolites provided by the diet and, in addition, metabolites derived from the microbiota hosted in the human large intestine which are partly absorbed and appear later in blood and urine (Fig. 9.1).

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Understanding Cancer Metabolism Through Global Metabolomics, these biochemicals, we are better able to identify and understand metabolic differences in cancer cells relative to normal cells. The focus of this chapter will be to better educate the reader about the importance of understanding cancer metabolism and how global metabolomics is an ideal technology for gaining these new insights.

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Mapping Metabolomic Quantitative Trait Loci (mQTL): A Link Between Metabolome-Wide Association Studstical tools required to map these traits onto the genome of this experimental population. Finally we describe network and systems biology strategies enhancing the biological interpretation of haplotype – metabotype association networks derived from mQTL studies for a better understanding of pathophysiological mechanisms.

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Metabolic Traits as Intermediate Phenotypes,igation of the genetics of the intermediate phenotype instead of investigating the genetics of the final endpoints allows the elucidation of this aspect of the disease. Optimal intermediate phenotypes are quantitative, easy to measure biochemical parameters. This results in an increased statistical power in contrast to qualitative phenotypes.

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上涨

Karsten SuhreAddresses a selected aspect of the genetic background to a metabolic phenotype.All chapters refer to one or more published experimental datasets.Looks at research about the intersection of genetics an

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sets.Looks at research about the intersection of genetics anThis book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.978-1-4899-9695-4978-1-4614-1689-0

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Book 2012This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

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