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Titlebook: Genetically Defined Animal Models of Neurobehavioral Dysfunctions; Peter Driscoll Book 1992 Springer Science+Business Media New York 1992

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Mouse Models of Human Trisomy 21 (Down Syndrome),ses due to meiotic nondisjunction of chromosome 21. This leads to three copies of chromosome 21 (trisomy 21, Ts21), the consequence of which is the development of characteristic features associated with Down syndrome (DS). Frequently seen in Down syndrome are dysmorphic features (facial, hands), con
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Genetic Animal Models of Krabbe Disease,). Its prevalence rate is approximately 1 per 50,000 in Sweden but is far lower in other countries. The mode of inheritance is autosomal recessive. The underlying cause of the disease is a genetic deficiency of the activity of a lysosomal hydrolase, galactosylceramidase (Suzuki and Suzuki, 1970).
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Genetic Animal Models of Epilepsy,epsy and antiepileptic drugs has mostly been done in mice and rats, in which seizures were induced by chemical or electrical means (Purpura et al., 1972; Löscher and Schmidt, 1988). Although these rodent models have proved useful for the development of new antiepileptic drugs, they are obviously not
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Genetically Selected Rat Lines as Models of Alcoholism and Alcohol Intoxication,950s (the UCh-A and UCh-B lines); four in the 1960s (LS, SS, AA, ANA); six more in the next decade (AT, ANT, MA, LA, P, NP); and 14 new lines have been developed in the 1980s (HAD, LAD, HAS, LAS, WSP, WSR, SEW, MEW, SLOW, FAST, HOT, COLD, plus a pair being developed as NIAAA). These 26 lines belong
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