Titlebook: Genes and Proteins Underlying Microbial Urinary Tract Virulence; Basic Aspects and Ap Book 2002

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Transcriptional Organisation and Regulation of , Group 2 Capsule Expressione expression regulated . and is capsule expression co-ordinated with the expression of other cell surface structures involved in disease?Answering these questions represents a fascinating biological problem.

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Analysis of the Hemolysin Determinants of the Uropathogenic , Strain 536 8 bp . motif).The dissimilar upstream elements may explain the different expression of the operons..Loss of the pathogenicity islands carrying the hemolysin determinants results in an avirulent phenotype.

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Use of the OmpS-display-system to Localize Thereceptor-bindingregion in the PapG Adhesin of Uropathombrane protein provides a means to transport them to the cell surface with a mechanism that is independent of their normal transport route. OmpS- display could be valuable when secreted components and contact-mediated signalling is characterized in bacteria.

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Urinary Tract Infection: From Basic Science to Clinical Applicationumber of non-. uropathogens will emerge. Especially nosocomial urinary tract infections will play a major role, because the number of eldery persons, persons receiving organ transplantation and chemotherapy and patients with other medical devices will increase. The analysis of urinary tract infectio

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Genetic Characterization of the Uropathogenic , Strain 536 — A Subtractive Hybridization Analysish are present in the pathogenic . strain 536 but absent from the non-pathogenic . strain MG1655 we have performed a subtractive hybridization analysis..We obtained diverse DNA fragments specific for the . strain 536. Sequence data of several cloned subtractive hybridization fragments showed a homolo

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Analysis of the Hemolysin Determinants of the Uropathogenic , Strain 536iptional rate..While the coding regions of the two . determinants are 96% homologous,no similarity can be found in the 5’ flanking regions (except the 8 bp . motif).The dissimilar upstream elements may explain the different expression of the operons..Loss of the pathogenicity islands carrying the he

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Functional Variability of Type 1 Fimbriae of hose of an avirulent K-12 strain PC31 do not. Amino acid residue Alanine-62 in the FimH is critical for the collagen binding ability: substitution of Ala. of IHE3034 FimH into serine abolishes collagen adhrence whereas substitution of Ser. of PC31 FimH into alanine restores the binding..Fimbriae als

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