Titlebook: Gene Therapy of Cancer; Peter Walden,Uwe Trefzer,Patricia Zambon Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusiv

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High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achie play a role in normal remodeling processes, e.g. fetal development, tissue repair, and angiogenesis, as well as in pathologic conditions, including rheumatoid arthritis, periodontitis, autoimmune blistering disorders of skin, tumor cell invasion, and metastasis (1).The activity of MMPs is specifica

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Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Grow[1]. ErbB-2 phosphorylates and interacts with Shc that participates inbetween active tyrosine protein kinases to Ras signaling pathway. A point mutation or an elevated expression of ErbB-2 results in oncogenic growth of cells.

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Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P45 using a mouse model system for pancreatic cancer. Human embryonic epithelial cells have been genetically modified to express the cytochrome P450 2B1 enzyme under the control of a CMV immediate-early promoter. This CYP2B1 gene converts oxazaphosphorines (ifosfamide or cyclophosphamide) to their acti

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Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral orino derivatives; the latter is a potent cytotoxic agent, which following further non-enzymatic reaction with thioesters, leads to the generation of interstrand crosslinks in DNA [1–4] (Figure 1a). These cannot be efficiently repaired by the cell, and lead to cell death. Nitroreductase and CB1954 are

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Characteristics of Cytosine Deaminase-5-Fluorocytosine Systemnzyme, present in bacteria and fungi but absent in mammalian cells, that deaminates cytosine to uracil. CD can also deaminate 5-fluorocytosine (5-FC) to toxic 5-fluorouracil (5-FU) [1], a potent chemoterapeutic and radiosensitizing agent. 5-FC has significant anticancer effect on tumors engineered t

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