| 书目名称 | Frontiers in Cerebral Vascular Biology | | 副标题 | Transport and Its Re | | 编辑 | Lester R. Drewes,A. Lorris Betz | | 视频video | | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions? What are the membrane proteins responsible for transport of specific substrates? What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro? What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics? Are brain vascular transport systems responsible for edema | | 出版日期 | Book 1993 | | 关键词 | Nervous System; biology; brain; central nervous system; development; gene expression; muscle; receptor; rese | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-2920-0 | | isbn_softcover | 978-1-4613-6267-8 | | isbn_ebook | 978-1-4615-2920-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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发表于 2025-3-21 17:32:38
