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楼主: 反抗日本
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https://doi.org/10.1007/978-3-322-83373-0ome efforts — like several other investigators [2, 3, 6, 7, 8] — to explore the fate of Asnase in the body, and I shall show in this paper that in our experiments Asnase has indeed some pharmacokinetic properties by which it differs considerably from other drugs.
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Studies on the Control of Asparagine Biosynthesis in Mammalian Tissues to ASNase. A similar phenomenon now appears to prevail following the clinical use of ASNase on human malignancies. A second anomoly existed in normal tissues. Those normal tissues tested showed no requirement for ASN and a resistance to ASNase, but only limited L-asparagine synthetase (ASN SYN) [4, 8, 17, 20].
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The Partitioning of L-Asparaginase between Blood and Lymphi-tumour effect of this enzyme. The purpose of this paper is to consider this problem in terms of what is already known about the extravasation of macro-molecules and also on the basis of experimental results obtained by observing the distribution of various samples of bacterial L-asparaginase in rats and sheep.
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Die Konstruktion der Untersuchungsgruppen The guinea-pig-L-asparaginase which they used failed to produce significant effects on the lymphosarcoma cells examined. Our studies of the morphological pattern were intended to provide insight into the possible mechanism by which L-asparaginase acts on cells and tissues.
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