Titlebook: Experimental Cholestasis Research; Mathieu Vinken Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug-induce

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LC-MS/MS Analysis of Bile Acids in In Vitro Samples,BA) and their conjugates in different matrices, such as plasma, blood, urine, and cell lysates. Numerous reports have indeed been published describing methods for quantitative determination of bile acids in plasma samples obtained during in vivo studies. However, information on bioanalytical methods

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,The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity, mechanism of cholestatic hepatotoxicity. Bile acids are synthesized in the hepatocyte, and excreted into the bile primarily by the bile salt export pump. Therefore, inhibition of the bile salt export pump by drugs has been postulated as a risk factor in the development of cholestatic hepatotoxicity

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In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids,drug candidates in preclinical drug development. Drug-induced cholestasis can be triggered by drugs that are inhibitors of the hepatic bile acid transporters. Therefore, it is of considerable interest in preclinical drug development to detect whether new candidate drugs can cause interference with t

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Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochpatocyte and biliary injury. As amphipathic molecules, bile acids can intercalate in lipid membranes, and pathophysiologic concentrations of bile acids have the potential to induce marked changes in the biophysical properties of biomembranes, including membrane ordering. These effects, particularly

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The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis,s, such as bile acids, during cholestasis, not only impairs liver function, but also affects other organs, including the kidneys. Although the precise mechanisms of cytotoxicity and organ injury in cholestasis are far from clear, oxidative stress and its subsequent events seem to play a central role