Titlebook: Experimental Cholestasis Research; Mathieu Vinken Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug-induce

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is. Cellular counter measures against those stressors are called adaptive stress response pathways. While in early stages of the disease adaptive stress pathways protect the hepatocytes, in later stages during prolonged stressed conditions they fail. The quantitative imaging-based assessment of cell

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,Umsetzung der Agilität in Unternehmen,the biliary system can be studied in mouse models. A particular focus is placed on mouse models for Alagille syndrome, a cholangiopathy with a strong genetic link to dysfunctional Notch signaling. Recently, a number of different genetic mouse models based on various manipulations of the Notch signal

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Generationen aus Sicht der Soziologieincluding choledocholithiasis, surgical trauma, and autoimmune disorders. Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. An extensively used experimental model to

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,Verschiedene Alter gut (zusammen)führen,tis represent relevant causes of chronic liver disease, associated to significant morbidity and mortality. To better understand and to address therapeutic strategies to cholangiopathies is essential to develop an in vivo model which recapitulates the pathological features of the disease. Chronic fee

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https://doi.org/10.1007/978-3-658-23712-7ver disease by 2 years of age. Despite re-establishment of biliary drainage following a Kasai portoenterostomy (surgical procedure), many infants develop fibrosis requiring liver transplant. In the murine model of biliary atresia, rhesus rotavirus infection of newborn pups results in a cholangiopath

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Fakten und Tendenzen im Wohnungswesen, due to pruritus, malnutrition, and complications from portal hypertension secondary to biliary cirrhosis. The zebrafish (.) has emerged as a valuable model organism for studying cholestasis that complements with the in vitro systems and rodent models. Its main advantages include conserved mechanism

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Heike Bruch,Florian Kunze,Stephan Böhmnt an appropriate surrogate to primary human hepatocytes for investigations on drug-induced cholestasis mechanisms. In this chapter, culture conditions for obtaining HepaRG hepatocytes and the main methods used to detect cholestatic potential of drugs are described. Assays for evaluation of bile can

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Methods in Molecular Biologyhttp://image.papertrans.cn/e/image/318815.jpg