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Titlebook: Experimental Cholestasis Research; Mathieu Vinken Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug-induce

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Hartmut Esser,Jürgen Friedrichsdrug candidates in preclinical drug development. Drug-induced cholestasis can be triggered by drugs that are inhibitors of the hepatic bile acid transporters. Therefore, it is of considerable interest in preclinical drug development to detect whether new candidate drugs can cause interference with t
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Aritra Acharyya,Arindam Biswas,Palash Daspatocyte and biliary injury. As amphipathic molecules, bile acids can intercalate in lipid membranes, and pathophysiologic concentrations of bile acids have the potential to induce marked changes in the biophysical properties of biomembranes, including membrane ordering. These effects, particularly
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Generation, Milieu und Geschlechttasis, i.e., apoptosis or necrosis, has been controversial. There are fundamental reasons for the controversies, both of which are discussed here, namely the design of experiments and the use of parameters with limited specificity for a certain mode of cell death. Based on the assumption that choles
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https://doi.org/10.1007/978-3-658-38736-5ated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated. In recent years, proteomics has been comprehensively applied in many research fields, including the pathogenesis, prognosis, and
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