Titlebook: Evolutionary Systems Biology; Advances, Questions, Anton Crombach Book 2021Latest edition The Editor(s) (if applicable) and The Author(s),

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Of Evolution, Systems and Complexity,concepts, tools and results. In particular, we will show how complex models can be used to explore this question and show that complexity can spontaneously accumulate even in simple conditions owing to a “complexity ratchet” fuelled by sign epistasis.

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Amnesty

Brittle

Book 2021Latest editionn focused on laying the foundations of evolutionary systems biology as an interdisciplinary field, where a way of thinking and asking questions is combined with a wide variety of tools, both experimental and theoretical/computational. Since publication of the first edition, evolutionary systems biol

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Direction and Constraint in Phenotypic Evolution: Dimension Reduction and Global Proportionality intraint in phenotypic evolution were formulated in terms of phenotypic fluctuation and the response against environmental change. The evolutionary relevance of slow modes in controlling high-dimensional phenotypes is discussed.

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Keratin

Addressing Evolutionary Questions with Synthetic Biology,cting these synthetic systems to experimental laboratory evolution provides a mechanistic understanding on important evolutionary questions, such as: Why did particular regulatory network topologies evolve and not others? What happens if we rewire regulatory networks? Could an expanded genetic code