Titlebook: Evolution of the Protein Synthesis Machinery and Its Regulation; Greco Hernández,Rosemary Jagus Book 2016 Springer International Publishin

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The Unique Evolutionary Distribution of Eukaryotic Elongation Factor 3,lower order eukaryotes. In agreement with its role as an ATPase, all the putative eEF3 homologs identified have two ABC domains. Critical residues of the two ABC domains involved in nucleotide binding and hydrolysis were highly conserved in all the putative eEF3 homologs identified, supporting the f

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Translational Control in Echinoderms: The Calm Before the Storm, evolutionary time. Combining biochemical, structural, cellular, and mathematical approaches, the analysis of the spatio-temporal dynamics of protein synthesis activation in different echinoderm model systems should provide insights into essential mRNA translation regulation occurring in physiologic

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Unique and Conserved Features of the Protein Synthesis Apparatus in Parasitic Trypanosomatid (, andnction in trypanosomatids including: (1) an expansion in the number of homologs of eIF4F subunits, leading to several novel eIF4F-like complexes; (2) changes in cytoplasmic ribosome structure and in its rRNA scaffold; (3) novel mechanisms of mitochondrial tRNA import; (4) a unique mitochondrial ribo

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Ergodic Theory and Differentiable Dynamicsin flexibility and suggest that tRNA molecules are building blocks of ribosomes and genomes. We make explicit the need to understand processes of molecular growth of macromolecules that would explain a primordial ribosome with both biocatalytic and genetic memory storage functions.

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https://doi.org/10.1007/978-3-319-74908-2d nature of the peptidyl transferase center (PTC), including where and how the peptide bond is made. This is followed by efforts to understand the subsequent evolution of the ribosome, which led to the addition and refinement of various other functional centers including the decoding center. This is

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https://doi.org/10.1007/978-1-4684-9488-4to the emergence of the nuclear membrane and split genes as well as the lack of both Shine-Dalgarno-like sequences in eukaryotic mRNAs and ribosomal protein S1. We discuss the possible evolutionary scenario where, during eukaryogenesis, mRNAs were perhaps translated in an IRES-dependent manner. It w

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