Titlebook: Epigenetic Alterations in Oncogenesis; Adam R. Karpf Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Epigenetic Therapies in MDS and AMLsignificant impact. In the past, therapies for these diseases were limited and patients who elected to receive treatment were subject to highly toxic, inpatient chemotherapeutics, which were often ineffective. In the era of hypomethylating agents (azacitidine and decitabine), a patient with high gra

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Methods for Cancer Epigenome Analysisn cancer are functionally important and clinically relevant, but even this well-studied area is continually re-evaluated in light of unanticipated results, such as the strong association between aberrant DNA methylation in adult tumors and polycomb group profiles in embryonic stem cells, cancer-asso

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Schlussbetrachtung und Ausblick,in coding genes. These actions are central to human health and are evidently aberrant in cancer. Central components of regulated gene expression are a variety of epigenetic mechanisms that include histone modifications. The post-translational modifications of histones are widespread and diverse, and

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Angela Nikelski,Annette Nauerthcert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and ge