Titlebook: Engineered Cell Manipulation for Biomedical Application; Misturu Akashi,Takami Akagi,Michiya Matsusaki Book 2014 Springer Japan 2014 Biode

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Engineering Cellular Assembly for Applications in Regenerative Medicineeriences in the body. Cells must be permitted to participate in an intricate communication network via biochemical and mechanical signaling with neighboring cells and key components of the extracellular matrix, something that is inherently lacking in monolayer cultures using petri dishes or flasks.

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Hepatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by Two- andons in biomedical research, drug discovery, and the treatment of liver disease. In this review, we provide an up-to-date overview of the wide variety of hepatic differentiation protocols. Moreover, we discuss the application of these protocols to three-dimensional culture systems in an attempt to in

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Building Experimental System Modeling Fibrotic Tissue in Human Pancreatic Cancer by Three-Dimensionareason why the cancer is so refractory to therapy has not yet been fully elucidated. We hypothesize that the characteristic of the “route” via which antitumor drugs reach the tumor cells is the factor responsible for the refractoriness. This factor should presumably be more critical for drugs with l

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Human Living Skin Equivalents as a Promising Model for Skin Graftsc proceeding was initially developed by the fundamental knowledge of biology in epidermal keratinocytes. The human skin induces terminal differentiation in the epidermis which overlays the dermis, a major extracellular matrix component in the skin. Importantly, the sub-epidermal basement membranes p

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Barrier Signallinglar barrier, such as occurs in the placenta, brain or eye, has a similar function. We show that a process of signalling across model barriers is possible in tissue culture but only when the barrier is bilayered or multilayered. This may be triggered by nanoparticle exposure but also by other factors

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