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Titlebook: Endorphins in Reproduction and Stress; Wolfgang Distler,Lutwin Beck Conference proceedings 1990 Springer-Verlag Berlin Heidelberg 1990 End

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Neurochemical Regulation of the LHRH Pulse Generatorulation. Their basic features are particularly clearly revealed in gonadectomized individuals (Fig. 1). Changes in LH pulse amplitudes and frequencies during the estrous cycle of the rat have been described (Fox and Smith 1985). In ovariectomized or postmenopausal women the pulse frequency is approx
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Differential Role of μ- and κ-Opiate Receptors in Anterior Pituitary Hormone Secretiontion with hypothalamic factors which are secreted into the hypothalamo-pituitary circulation (for review see Illes 1989; Pfeiffer and Herz 1984; Millan and Herz 1985). The presence of at least three distinct types of opiate receptors named μ (my), δ (delta) and κ (kappa) is generally accepted and li
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Role of β-Endorphin in the Ovary: In Vitro Studies of Porcine Ovaries and Individual Folliclesha et al. 1984; Aleem et al. 1986; Adams and Cicero 1989). Concentrations of β-endorphin in ovarian follicular fluid were reported to be significantly higher than in peripheral blood, suggesting a local ovarian secretion (Petraglia et al. 1985; Aleem et al. 1987). Recently, a periovulatory increase
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Human Plasma β-Endorphin Levels in Pregnant Women and in Newbornshe peripheral plasma of women (a) during pregnancy, in labor, and after delivery; (b) in labor without and with epidural anesthesia; and (c) prior to and after induction of general or regional anesthesia for cesarian section. There have been also determinations of β-endorphin in the umbilical arteri
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Opioid Peptides and Stress: The Sympathetic Nervous System and Pituitary-Adrenal Axisthe peptides themselves and their putative receptors especially concentrated in nuclei concerned with neuroendocrine regulation, particularly the hypothalamus. Whatever their direct effects on gonadal function, opioid peptides can indirectly modulate reproductive fitness by regulating the output and
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Opioidergic Control of the Pituitary-Adrenal Axiscontrol of pituitary hormone secretion. In man, opiates have been shown to inhibit the pituitary-adrenal axis (Grossmann 1983). Thus, β-endorphin suppresses basal ACTH and Cortisol secretion (Taylor et al. 1983). Similarly, the δ-opiate receptor agonist morphine sulfate reduces baseline Cortisol con
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