Titlebook: Endolysosomal Voltage-Dependent Cation Channels; Christian Wahl-Schott,Martin Biel Book 2023 Springer Nature Switzerland AG 2023 Endo-lyso

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Electrophysiological Techniques on the Study of Endolysosomal Ion Channelshysiological properties of these ion channels in the intracellular organelle membrane cannot be observed using conventional electrophysiological techniques. This section compiles the different electrophysiological techniques utilized in recent years to study endolysosomal ion channels and describes

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The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channelslocalization in the membranes of endo-lysosomes, intracellular compartments of submicrometric dimensions, makes their study difficult with usual electrophysiological techniques. In this work, we show how the plant vacuole, a versatile organelle that can occupy up to 90% of the volume in mature plant

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Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channelstch clamp technology, it has become possible to directly measure ion channel currents across endolysosomal membranes. Members of the transient receptor potential (TRP) cation channel family, namely the endolysosomal TRPML channels (TRPML1-3), also called mucolipins, as well as the distantly related

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