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Titlebook: Endocytosis; Ira Pastan,Mark C. Willingham Book 1985 Plenum Press, New York 1985 cell.cells.growth.growth factor.hormone.hormones.molecule

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发表于 2025-3-21 18:17:24 | 显示全部楼层 |阅读模式
书目名称Endocytosis
编辑Ira Pastan,Mark C. Willingham
视频video
图书封面Titlebook: Endocytosis;  Ira Pastan,Mark C. Willingham Book 1985 Plenum Press, New York 1985 cell.cells.growth.growth factor.hormone.hormones.molecule
描述Many hormones, growth factors, and other large molecules bind to speci­ Jic receptors on the surface of eukaryotic cells and are rapidly taken into these cells. Current techniques of protein purification have made available sufficient amounts of these molecules so that detailed studies of their interaction with cells could be carried out. These studies have been performed on just a few types of cells, but it is clear that all types of cells carry out a_ similar internalization process. The realization that cells rapidly internalize hormones, growth factors, transport proteins, toxins, and viruses has led many investigators to address a similar series of questions: (1) What is the pathway by which macromolecules enter cells? (2) Do all macromolecules enter by the same pathway? (3) What is the function of internalization of large molecules? (4) What is the biochemical mechan­ ism of internalization? In this volume we have tried to provide answers to these and related questions. To do this we have asked scientists currently active in the field to contribute chapters in their special areas of interest. The selection of the material covered reflects in large part areas of active researc
出版日期Book 1985
关键词cell; cells; growth; growth factor; hormone; hormones; molecule; protein; proteins; research; transport
版次1
doihttps://doi.org/10.1007/978-1-4615-6904-6
isbn_softcover978-1-4615-6906-0
isbn_ebook978-1-4615-6904-6
copyrightPlenum Press, New York 1985
The information of publication is updating

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Receptors,ical effects through the initial interaction with specific receptors. Even lysosomal enzymes reach their target, the lysosome, through a receptor-mediated pathway that is initiated by the binding of the newly synthesized enzyme to a specific receptor. The binding of the ligand to its specific recept
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Chemical and Physical Properties of the Hepatic Receptor for Asialoglycoproteins,ention of biochemists and cell biologists. These questions have been resolved, at least partially, by the application of new and highly sensitive analytical techniques for the sequential analysis of carbohydrate chains. In general, the constituent monosaccharides appear to form a common and recogniz
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Transferrin: Receptor-Mediated Endocytosis and Iron Delivery,utionary solution to the problem of sequestering aqueous ferric ions. In microbes the family of proteins known as siderochromes serve functions that are formally analogous to transferrin. In vertebrates, transferrin and the intracellular iron storage protein ferritin provide an efficient mechanism f
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Polymeric IgA and Galactose-Specific Pathways in Rat Hepatocytes: Evidence for Intracellular Ligandbert Einstein, New York, described the specific uptake by hepatocytes of galactose-exposing proteins and their rapid degradation in lysosomes. The same year, Brandtzaeg (1974), at the Institute of Pathology of the Rikshospitalet, Oslo, Norway, proposed a model for the selective transfer of polymeric
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Acidification of Endocytic Vesicles and Lysosomes,studied example of this regulation is the proton pumping involved in formation of ATP by mitochondria (Mitchell, 1976). Other examples include the extrusion of H. across the plasma membrane and the acidification of intracellular organelles such as lysosomes, endocytic vesicles, and secretory granule
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Mathematical Modeling of Receptor-Mediated Endocytosis,ling. Much progress has been made in the ability to define and measure individual steps in the complex multistep process of endocytosis, and the use of radiolabeled ligands makes quantitative kinetic data accessible to the modeler. In this chapter we briefly explore the role of mathematical modeling
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Morphologic Methods in the Study of Endocytosis in Cultured Cells,nd intracellular traffic. In general, a specific “handle” on the ligand or the receptor is required. This can take the form of specific antibodies to these components, the direct visualization of the ligand in the case of viral particles, or specially prepared cytochemical markers for the ligand- re
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