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Titlebook: Electrophysiology of Unconventional Channels and Pores; Anne H. Delcour Book 2015 Springer International Publishing Switzerland 2015 elect

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书目名称Electrophysiology of Unconventional Channels and Pores
编辑Anne H. Delcour
视频video
概述Timely book on the structure and function of unconventional pores.Covers non-canonical channels and pores of all origins.Written by international experts from different fields
丛书名称Springer Series in Biophysics
图书封面Titlebook: Electrophysiology of Unconventional Channels and Pores;  Anne H. Delcour Book 2015 Springer International Publishing Switzerland 2015 elect
描述.This book is dedicated to the channels and pores that belong to an eclectic and ubiquitous class of unconventional - perhaps at times strange - pore-forming molecules, which nevertheless play fundamental roles in various organisms. These non-canonical channels may take on various and sometimes complex architectures, such as large beta-barrels or lipid-containing pores. They may originate from bacteria, viruses or intracellular organelles. For some of them, the physiologically relevant substrate may indeed be ions, and for others folded polypeptides. Some are released by cells in a soluble form that has the ability to insert into biological membranes to exert its permeabilizing effect. Many of these unconventional pores have been investigated by electrophysiology, which, by its virtue of focusing on a few or even a single unit, has provided invaluable insight into the mechanisms and structure-function relationships of these remarkable membrane entities. The chapters of this book highlight a representative set of these interesting investigations..
出版日期Book 2015
关键词electrophysiology; membrane channels; non-canonical channels; patch clamp; pore forming; unconventional p
版次1
doihttps://doi.org/10.1007/978-3-319-20149-8
isbn_softcover978-3-319-37235-8
isbn_ebook978-3-319-20149-8Series ISSN 0932-2353 Series E-ISSN 1868-2561
issn_series 0932-2353
copyrightSpringer International Publishing Switzerland 2015
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Springer Series in Biophysicshttp://image.papertrans.cn/e/image/306524.jpg
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Is Caring for Elders an Act of Altruism?t state of assembly and disassembly. Electrophysiological and electron microscopic evidence strongly supports the formation of cylindrical barrel-stave channels with the staves oriented in an anti-parallel fashion. Molecular-dynamic simulations concur that the proposed structure is stable and viable
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Doing Generation, Performing the Mission,ria, they often constitute one of the components of molecular machines that participate in membrane biogenesis, assembly of surface exposed appendages, and the secretion of protein substrates across the cell envelope. Their pore-forming properties make them directly amenable to electrophysiology, ev
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