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Titlebook: Electrical Diseases of the Heart; Genetics, Mechanisms Ihor Gussak (Deputy Therapeutic Area Head, Profess Book 20081st edition Springer-Ver

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Basic Physiology of Ion Channel Functionl to generate action potentials and is also summed up in time and space to generate a surface electrocardiogram (EKG) signal. Thus cardiac electrophysiology offers the unique opportunity to obtain different levels of view of the same phenomenon either nanoscopically (at the level of a channel pore)
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Mechanisms of Action of Antiarrhythmic Drugsecently treatment of atrial tachyarrhythmias such as atrial fibrillation is also one of the major interests. However, its application may cause serious adverse effects.. Since usage of antiarrhythmic drugs tended to rely on clinicians’ experience and to be based on clinical practice, the effects of
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The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribu The mechanisms and consequences of sodium and calcium overload are the subject of this review. Evidence supporting a role for the late sodium current (late . .) as a mechanism of calcium overloading and cardiac dysfunction is emphasized.
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Senescence and Arrhythmogenesise in understanding the pathogenesis of age-related cardiac diseases and therapies are being developed for these diseases, advanced age by itself poses significant dilemmas in therapy due to the lack of a full understanding of the molecular basis for the aging-associated increase in the susceptibilit
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