Titlebook: Designer Receptors Exclusively Activated by Designer Drugs; Gerald Thiel Book 2015 Springer Science+Business Media New York 2015 CNO-stimu

Chemotherapy

废墟

The Use of DREADDs (Designer Receptors Exclusively Activated by Designer Receptors) in Transgenic M describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

euphoria

CORE

锡箔纸

Design and Analysis of an Arrestin-Biased DREADD,GPCR function and biology. These mutant muscarinic receptors are unable to bind acetylcholine (ACh), the endogenous muscarinic receptor ligand, but can be efficiently activated by clozapine-N-oxide (CNO), an otherwise pharmacologically inert compound. These CNO-sensitive designer GPCRs (alternative

analogous

,Regulation of Gene Transcription Following Stimulation of Gαq-Coupled Designer Receptors,imately leads to transcriptional changes. We have designed reporter genes that specifically measure the activities of the stimulus-responsive transcription factors AP-1, CREB, Egr-1, and serum response factor/ternary complex factor. The transcriptional activation potential of CREB and Elk-1 is measu

ARENA

凹处

Dissecting Neuronal Circuits Involved in Olfactory-Mediated Behaviors,y, sensory neurons establish synapses with principal neurons of the olfactory bulb (OB), where the earliest stages of odor processing occur. Unlike other sensory systems, output neurons in the OB project to the olfactory cortex bypassing the thalamus. Therefore, neural circuits in the OB, and odor p

感染

The Use of DREADDs (Designer Receptors Exclusively Activated by Designer Receptors) in Transgenic Mthe brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of spe

CAPE