Titlebook: Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases; R. Numerof,C. A. Dinarello,K. Asadullah Conference proceedings

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,Cytokine Targeting in Psoriasis and Psoriatic Arthritis: Beyond TNFα, studies have elucidated the presence of numerous cytokine and chemokine activities in psoriatic skin and synovium. There is considerable interest in the potential of such activities as novel therapeutic targets. IL-15 is an innate response cytokine that activates leukocyte subsets via binding to it

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Inhibitors of Histone Deacetylases as Anti-inflammatory Drugs,ibition of inflammation. The review focuses on both in vitro and in vivo models of inflammation and autoimmunity. Of particular interest is the inhibition of pro-inflammatory cytokines. Although the reduction in cytokines appears paradoxical at first, upon examination, some genes that are anti-infla

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TNF Blockade: An Inflammatory Issue,d metastasis. In addition, dysregulation of TNF has been implicated in a wide variety of inflammatory diseases including rheumatoid arthritis, Crohn’s disease, multiple sclerosis, psoriasis, scleroderma, atopic dermatitis, systemic lupus erythematosus, type II diabetes, atherosclerosis, myocardial i

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IL-1 Family Members in Inflammatory Skin Disease, known as IGIF), has also been realized to be an IL-1 family member and to possess significant inflammatory activity. Half a dozen additional members of the IL-1 family have been identified in recent years, and given their relatedness to IL-1 and IL-18, it is tempting to speculate that they too migh