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Titlebook: Cytokines and Pain; Linda R. Watkins,Steven F. Maier Book 1999 Springer Basel AG 1999 Arthritis.central nervous system.cytokine.growth.hea

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发表于 2025-3-21 17:59:41 | 显示全部楼层 |阅读模式
书目名称Cytokines and Pain
编辑Linda R. Watkins,Steven F. Maier
视频videohttp://file.papertrans.cn/243/242644/242644.mp4
丛书名称Progress in Inflammation Research
图书封面Titlebook: Cytokines and Pain;  Linda R. Watkins,Steven F. Maier Book 1999 Springer Basel AG 1999 Arthritis.central nervous system.cytokine.growth.hea
描述Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cyto
出版日期Book 1999
关键词Arthritis; central nervous system; cytokine; growth; health care; inflammation; neoplasm; nervous system; pa
版次1
doihttps://doi.org/10.1007/978-3-0348-8749-6
isbn_softcover978-3-0348-9756-3
isbn_ebook978-3-0348-8749-6Series ISSN 1422-7746 Series E-ISSN 2296-4525
issn_series 1422-7746
copyrightSpringer Basel AG 1999
The information of publication is updating

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发表于 2025-3-21 22:55:31 | 显示全部楼层
Evolutionary perspectives of cytokines in pain, ability is as important to invertebrates as it is to vertebrates, a fact that is underscored by behavioral evidence for the display of nociceptive behaviors in invertebrates (reviewed in [., .]. For example, locomotion away from a noxious stimulus has been observed in the simplest animals (see Fig.
发表于 2025-3-22 02:26:41 | 显示全部楼层
Illness-induced hyperalgesia: Mediators, mechanisms and implications,lgesia from an adaptive perspective and makes the argument that exaggeration of pain is a natural and normal consequence of immune activation. During illness, infection, and injury, activated immune cells release substances that signal the brain, triggering a constellation of coordinated responses d
发表于 2025-3-22 07:04:18 | 显示全部楼层
Hyperalgesia from subcutaneous cytokines,et cells. Cytokines may be produced by more than one cell type and in a number of tissues and may work in an autocrine, paracrine, or endocrine manner. All cytokines are small proteins (typically 5-30 kDa), some are glycoproteins, and some are synthesised as larger precursors which are cleaved to gi
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Brain cytokines and pain, manifestation of inflammation in response to local cellular injury, e.g. edema, migration of immunocompetent cells, local hyperthermia and hyperalgesia. These cytokines, when given peripherally, induce such inflammatory responses at local sites, and local hyperalgesia is caused by the sensitizing e
发表于 2025-3-23 02:05:38 | 显示全部楼层
Interleukin-1 and tumor necrosis factor: Rheumatoid arthritis and pain,tates. Women are more commonly affected than men (average ratio is 3:1), and the disease produces substantial morbidity as well as an increase in mortality [.]. Although the etiology of RA is unknown, it is generally agreed that it represents an autoimmune disease that involves both the humoral and
发表于 2025-3-23 06:14:56 | 显示全部楼层
Evolutionary perspectives of cytokines in pain,, the marine mollusc ., and their modification by a variety of stimuli have been studied extensively over the last two decades. . display a variety of nociceptive behaviors in response to noxious mechanical or electrical stimulation including local body withdrawal, ink and opaline release, and escap
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