Titlebook: Cytokine Knockouts; Giamila Fantuzzi Book 2003Latest edition Springer Science+Business Media New York 2003 Chemokine.Immune System.autoimm

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The Use of Cytokine Knockouts to Study Host Defense Against Infectionbute to host defense mechanisms using the very same molecular and cellular pathways involved in chronic inflammation, tissue destruction, and tissue remodeling. How does one reconcile the existence of two opposing outcomes for the host—one clearly not in the interest of survival and another vital to

哥哥喷涌而出

IL-1 Receptor Antagonist-Deficient Mice The disturbed balance of activity of the IL-1 system, even though it is part of the innate immune system, appears to feed into the activity of the adaptive immune response, creating autoimmune conditions. Investigating the mechanism for this specificity may well yield important insights into the na

Commission

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Role of IL-5 in Immune and Pathological Responses in the Mouse pathways coexist in many disease and immune responses. Importantly, studies in IL-5. mice are disclosing an important role for this cytokine in the regulation of immune responses by modulating lymphocyte function.

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IL-10 and IL-2 Knockout Mices of CD4+ and CD8+ T cells, as well as B220+ B cells, suggesting that both T and B cells are spontaneously activated in the colonic immune response. As in the IL-10 deficient mouse, disease in the IL-2-deficient mouse is dependent upon the presence of luminal microflora and is modulated by the genet

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Confidential

IL-13 and Double IL-4/IL-13 Knockout Miceeneration of AHR. The roles of IL-4 and IL-13 have obvious implications for the development of therapeutic strategies for cytokine/anti-cytokine modulation of immune reactions. The use of conventional transgenic mice and gene knockout mice has already provided important functional information regard