Titlebook: Cytochrome P450; Structure, Mechanism Paul R. Ortiz Montellano Book 1995Latest edition Springer-Verlag US 1995 NADPH.Oxidation.biochemistry

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n to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem st

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P. M. Honoré,R. Jacobs,H. D. Spapenlly oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such as agents that interfere with the electron supply to the hemoprotein by accepting electrons directly from cytochrome P450 reductase,. are not discussed here.

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Models and Mechanisms of Cytochrome P450 Actionn and olefin epoxidation, particularly, have attracted a sustained worldwide effort, the allure deriving from both a desire to understand the details of biological oxygen activation and transfer and, as well, the sense that catalysts for the practical application of these principles to organic synth

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Twenty-five Years of P450cam Research, seminal breakthroughs have been made in mammalian P450s through work with microsomal fractions. and the astounding tour de force accomplishments in the purification of membrane-bound P450 systems originally initiated by Coon and his colleagues.. However, it was generally realized by the early 1980

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Structural Studies on Prokaryotic Cytochromes P450wealth of biochemical and biophysical studies on P450., the high-resolution crystal structure became available in 1987.. This was followed by a series of structures on various inhibitor/substrate complexes which revealed some key structure-function relationships in P450s. In addition, with the devel

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NADPH Cytochrome P450 Reductase and Its Structural and Functional Domainsction and trypsin treatment of a protein that catalyzed the reduction of cytochromes .. Since that initial report, much information has been revealed and reported about the nature, reactivities, structure, and regulation of the reductase that we have come to recognize as a component of the cytochrom

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