Titlebook: Current Perspectives in microRNAs (miRNA); Shao-Yao Ying Book 2008 Springer Science+Business Media B.V. 2008 DNA.Microarray.RNA Splicing.S

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Wandel der Sozialreputation von Unternehmen,hanisms implicated in Parkinson disease; or enhance neurodegeneration in Drosophila model induced by proteins implicated in polyQ neurodegenerative pathologies. Loss of FMPR protein function is a cause of common mental retardation syndrome (FXS) and function of FMRP or FMPR-related protein in . (Dfm

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Sozialreputation in der Mediengesellschaft,i-miRNAs). MiRNA mutations/SNPs might disrupt miRNA functions by affecting miRNA transcription, miRNA bio-processing or miRNA-target interaction. We found that the density of SNPs at miRNA-binding sites of miRNA targets is significantly lower than that of SNPs located in the 3′-UTRs of human genes,

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Ataxia

https://doi.org/10.1007/978-3-531-90727-7alls with neointimal formation. Interestingly, modulating an aberrantly overexpressed miRNA, miR-21, via antisense-mediated depletion (knock-down) had a significant negative effect on neointimal lesion formation. Vascular smooth muscle cell (VSMC) is the major cellular component within the neointima

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t, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide sig978-90-481-7903-9978-1-4020-8533-8

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Structures of MicroRNA Precursors, processing of microRNA transcripts involves the activities of two RNase III enzymes Drosha and Dicer. In this study we analyzed structural features of human microRNA precursors that make these transcripts Drosha and Dicer substrates. The structures of minimal functional primary precursors (pri-micr

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Small RNA Technologies: siRNA, miRNA, antagomiR, Target Mimicry, miRNA Sponge and miRNA Profiling,ife sciences. Small RNAs, namely small interfering RNA (siRNA) and microRNA (miRNA), not only play key roles in down regulating gene expression, controlling growth and development, stress response, and various diseases, but also serve as essential tools for the study of gene functions. In this chapt

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RNA Interference Expression Vectors Based on miRNAs and RNA Splicing,ccurs naturally within cells to regulate gene expression at the post-transcriptional level. The development of reliable RNAi vectors encoding artificial and natural miRNAs would be useful tools for many RNAi applications. Here, we describe two new RNAi vectors, designated pSM155 and pSM30, that take