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Titlebook: Coordinated Regulation of Gene Expression; R. M. Clayton,D. E. S. Truman Book 1986 Plenum Press, New York 1986 DNA.biology.cell.cell biolo

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Carving: Hulme, Pound, Stokes and Sweeney,rrangement of genetic material found in immunoglobulin producing cells of vertebrates, and a few instances of selective loss or amplification of regions of DNA found in various invertebrate species, it is generally supposed that the genome is constant throughout the range of cell types of an individ
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Carving: Hulme, Pound, Stokes and Sweeney,erally assumed that the structural organization of chromatin determines the state of differentiation and activity of eukaryotic genes. Our work is aimed at understanding the molecular details of the processes which prepare genes to be differentially and coordinately expressed.
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d within regions of erythroid specific DNAsel hypersensitivity. There is also a prominent DNAsel hypersensitive site 6.5 kb upstream of the major cap site which corresponds to an unusual nucleotide sequence. The upstream promoters can be regulated independently of the major cap site in response to a
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