Titlebook: Connexins; A Guide Andrew L. Harris,Darren Locke Book 2009 Humana Press 2009 biochemistry.biology.chemistry.development.genes.membrane.morp

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Voltage-Gating Mechanisms of Connexin Channelsively for homomeric Cx26 and Cx32 hemichannels. These studies have shown that difference in gating polarity of Cx26 and Cx32 hemichannels results from a difference in the charge of the second amino acid residue. The voltage polarity to which Cx32 hemichannels close can be reversed by negative charge

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Gap Junction Morphology and Dynamics in Situr channels. This is not the case for connexin hemichannels in nonjunctional membranes, which actively traffic laterally within the plasma membrane to plaques in cell–cell apposition areas. Moreover, connexin-interacting proteins may contribute to regulation of how connexin channels pack in gap junct

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Connexins in the Nervous Systemnly to astrocytes, most via heterotypic Cx43–Cx47 or Cx30–Cx32 junctions. These junctions, along with those between astrocytes, may play a role in spatial buffering of K. ions and neurotransmitters, and may influence severity of tissue damage during ischemia. Mutations in CX47 cause Pelizaeus Merzba

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Foreword: Gap Junctions and Emergent Organ Properties

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