Titlebook: Concepts in Viral Pathogenesis II; Abner Louis Notkins,Michael B. A. Oldstone Textbook 1986 Springer Science+Business Media New York 1986

Infant

Dna262

阻塞

Genetic Engineering of Vaccinia Virus Vectors: Development of Live Recombinant Vaccinestual eradication of a dreaded disease. Because the last natural case of smallpox occurred eight years ago, the need for vaccination is over. Recently, however, the heretical notion that vaccinia virus might be used for immunoprophylaxis of other diseases was suggested [1–4]. Simply stated, by isolat

Baffle

Viral Enhancer Elementsrototype enhancer element, the 72-bp repeat of SV40, was first shown to be an essential set of sequences required for the efficient transcription of SV40 early genes [3–5]. Although there is some variability in the sequences that we have come to know as enhancers, in general their definition involve

Antagonist

Amplification of Proto-oncogenes in Tumorigenesis) lesions that alter the expression of otherwise normal genes, and (b) lesions that change the functions of gene products. Both have been found, and both may play a role in the genesis of human neoplasia [1]. Here I review the evidence that one often-neglected genetic abnormality—the spontaneous amp

踉跄

Multistep Scenarios in Tumor Development and the Role of Oncogene Activation by Chromosomal Translocultiple changes [1–3]. Cell proliferation is often dependent on the interaction between specific growth factors and their receptors on the target cell surface. Such receptors usually appear in relation to maturation switches induced by specific signals. After the cell has been determined to enter a

有斑点

缺陷

Oncogenes, Growth Factors, and Receptorsmodel systems provided by these viruses have proven to be valuable sources of information not only on the mechanisms by which normal cells become malignant, but also on how they grow and differentiate. The acutely transforming retroviruses contain genes, termed ., that are responsible for causing tu