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Titlebook: Computer Models in Biomechanics; From Nano to Macro Gerhard A. Holzapfel,Ellen Kuhl Conference proceedings 2013 Springer Science+Business M

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Simulations of Cell Behavior on Substrates of Variegated Stiffness and Architectureocal adhesions and stress fibers. We employ a biochemomechanical model implemented in a finite element framework to simulate cell response on substrates of variegated stiffness and architecture. We perform simulations to generate stress fiber and focal adhesion distributions, and predict the values
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A Coupled Chemomechanical Model for Smooth Muscle Contractionain-energy function, additively decomposed into passive parts and an active calcium-driven part related to the chemical contraction of smooth muscle cells. For the description of the calcium phase the four state cross-bridge model of Hai and Murphy (Am. J. Physiol. 254:C99–106, .) has been used. Bef
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Modeling of Smooth Muscle Activationon concentration. A homogeneous model for smooth muscle contraction is derived in this paper by using a continuum thermodynamical framework. The model is based on an additive decomposition of the deformation, and balance laws for the mechanical and electrochemical scales are obtained using the princ
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Multiscale Modeling of Arterial Adaptations: Incorporating Molecular Mechanisms Within Continuum Bio for improving the design of clinical interventions. Although these models are most appropriate to the clinical scale of observation, the underlying mechanisms responsible for such remodeling occur at the molecular scale. The goal of this chapter is to review a validated continuum level model of art
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Cardiovascular Tissue Damage: An Experimental and Computational Frameworke and predict damage due to mechanical loading and applies this framework to arterial clamping. An extension of the Holzapfel-material model for arterial tissue is presented, incorporating smooth muscle cell activation and damage to the different constituents. It is implemented in a finite element f
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Mechanical Properties of Ascending Thoracic Aortic Aneurysm (ATAA): Association with Valve Morphologr death. AoD represents a devastating separation of elastic aortic layers occurring when the hemodynamic loads on the diseased wall exceed the adhesive strength between layers. The goal of this study was to evaluate and compare the dissection properties of non-aneurysmal and aneurysmal human ascendi
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Intracranial Aneurysms: Modeling Inception and Enlargementse and lead to improved criteria to assist diagnostic decisions. We briefly review the literature and present novel models on two topical areas of research activity: modeling IA inception and modeling IA evolution. We present a novel computational methodology to remove an IA and reconstruct the geom
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