Titlebook: Computational Systems-Biology and Bioinformatics; First International Jonathan H. Chan,Yew-Soon Ong,Sung-Bae Cho Conference proceedings 20

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Study of the Structural Pathology Caused by CYP2C9 Polymorphisms towards Flurbiprofen Metabolism UsiC9 has several allelic variant forms each of which arises from single amino acid substitution and could reduce/increase enzyme activities and affect drug metabolism. Mutant alleles may cause serious toxicity in some narrow therapeutic index drugs. CYP2C9*13, one of the CYP2C9 variant forms that is c

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Sequential Application of Feature Selection and Extraction for Predicting Breast Cancer Aggressiveneherapy to survive. Using microarray based technology and various feature selection techniques, a number of prognostic gene expression signatures have been proposed recently. It has been shown that these signatures outperform traditional clinical guidelines for estimating prognosis. This paper studie

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Mining LINE-1 Characteristics That Mediate Gene Expressionected from L1Base and GSE3167. The memory-efficient data structure called FP-Tree was employed to enumerate all frequent item sets. The frequent item sets were then used to produce rules for predicting “down regulation” and “not down.” Each rule was assigned a p-value by means of Chi-square test. No

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Prediction of Non-coding RNA and Their Targets in , Genomeegulatory roles. Efforts to identify the whole set of ncRNAs and then to elucidate their functions would gain better biological understanding. Although ncRNA is another type of genome constituent, most of the genes for ncRNA are overlooked by standard genome annotation of genome sequencing projects.

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Reconstruction of Starch Biosynthesis Pathway in Cassava Using Comparative Genomic Approachly used as food, feed and raw materials for biochemical industries. Due to the increasing demand of cassava starch, the starch biosynthesis pathway is thus of interest for metabolic engineering, aiming at strain improvement. However, the uncertainties in the metabolic pathway of starch biosynthesis

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