Titlebook: Computational Physiology; Simula Summer School Kimberly J. McCabe Book‘‘‘‘‘‘‘‘ 2023 The Editor(s) (if applicable) and The Author(s) 2023 Op

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Electromechanical , Testing Alters Predicted Drug-Induced Risk to Develop Torsade de Pointes,rhythmia Assay (CiPA) is a novel testing paradigm that utilizes single cell electrophysiological simulations to predict TdP risk for drugs that could potentially be used clinically. However, the effects on mechanical performance and mechano-electrical feedback are neglected. Here, we demonstrate tha

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Realizing Synaptic Signal Transmission During Astrocyte-Neuron Interactions within the EMI Frameworing glial cells. Despite extensive research, the effects of glial cells, such as astrocytes, on signal transduction between neurons are not fully understood. The Kirchhoff-Nernst- Planck (KNP) and Extracellular-Membrane-Intracellular (EMI) models constitute a promising framework for modeling these k

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Recapitulating Functional Heterogeneity in Electrophysiologically Active Tissues, degree to which variation in PoM outputs (e.g. action potential duration) matches experimentally observed variation. We report that this “ground-up” approach underestimates functional heterogeneity in the hiPSC-CM population, but overestimates it in adult human cardiomyocytes. In cont