Titlebook: Computational Methods for Drug Repurposing; Quentin Vanhaelen Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019

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Hector Jensen,Costas Papadimitrioua novel and exciting application called drug repositioning. Several computational methods try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter we present an in-depth review of data resources and computational models for drug repositioning.

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Hector Jensen,Costas Papadimitrioution on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of small molecules offers opportunities to explore the repurpose-able potential of existing pharmacopoeia. This method gains further importance, especially, in the con

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https://doi.org/10.1007/978-3-030-12819-7million clinical studies. Mining such rich and clean clinical summary data could be helpful to many health-related researches. Described here is a method that utilizes serious adverse event data to identify potential new uses of drugs and dietary supplements (repositioning).

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Hector Jensen,Costas Papadimitrioua novel and exciting application called drug repositioning. Several computational methods try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter we present an in-depth review of data resources and computational models for drug repositioning

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Eric A. Vittoz,Christian C. Enzemical and molecular features were used in drug similarity calculation. In this paper, we first extracted drug chemical structures and drug-target interactions. Second, we computed chemical structure similarity and drug- target profile similarity. Further, we constructed a bipartite graph model with

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Analog Circuits in Weak Inversion,rugs for new indications. It provides the quickest possible transition from bench to bedside. In essence, computational strategies are appealing because they putatively nominate the most encouraging candidate for a given indication. A wide range of computational methods exist for repositioning. In t