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Titlebook: Clinical Pharmacology: Current Topics and Case Studies; Markus Müller (Professor and Head of Department) Book 20101st edition Springer-Ver

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Observational studies studies seemed to gradually displace observational research in the field of clinical pharmacology, because they permitted fair comparisons at much higher levels of internal validity. An important breakthrough of this concept was seen after Archie Cochrane had published his very influential book on effectiveness and efficiency in 1972 [2].
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Tools in clinical pharmacology - imaging techniquesetic resonance imaging (MRI), X-ray computed tomography (CT) or ultrasound imaging. Furthermore there is the up-and-coming possibility to combine different imaging modalities such as PET/CT, SPECT/CT, and MRI/PET in order to match functional to anatomical information.
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Safe Filler Injection Techniques. In general, drug development is ideally a step-wise procedure in which information gained from early, typically smaller, studies is used to plan and perform larger studies with more detailed objectives.
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https://doi.org/10.1007/978-94-6091-936-7r clinical decision making emerged as they were correlated with the pathology and the clinical course of disease states. This “traditional identification” of biomarkers as an observational site product of clinical practice led to the identification of the majority of clinical biomarkers employed in clinical practice today.
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Phase-I studies and first-in-human trials. In general, drug development is ideally a step-wise procedure in which information gained from early, typically smaller, studies is used to plan and perform larger studies with more detailed objectives.
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