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Titlebook: Clinical Aspects of Microdialysis; Aminadav Mendelowitsch,Helen Langemann,Otmar Gratz Conference proceedings 1996 Springer-Verlag/Wien 199

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书目名称Clinical Aspects of Microdialysis
编辑Aminadav Mendelowitsch,Helen Langemann,Otmar Gratz
视频video
丛书名称Acta Neurochirurgica Supplement
图书封面Titlebook: Clinical Aspects of Microdialysis;  Aminadav Mendelowitsch,Helen Langemann,Otmar Gratz Conference proceedings 1996 Springer-Verlag/Wien 199
描述Microdialysis is a minimally invasive method which enables continuous monitoring of parameters in the extracellular space of various tissues. It has been investigated in animal models for over a decade, and many publications have provided insight into its advantages and disadvantages. However, in spite of its enormous potential for revealing metabolic processes in normal and pathological tissue, microdialysis in humans is still in its infancy. Clinical neurointensive medicine nowadays demands much more than conventional monitoring methods. As already shown by jugular bulb measurements of oxygen and lactate, in the future clinicians will want to have access to continuous neurochemical information from the patient. This information could be used to prevent those enigmatic secondary lesions which play such a negative role in neurointensive medicine, or at least enable treatment of them at an early stage. The extensive information now available from the laboratory would help with the interpretation of clinical analogues. In the University Clinic of Neurosurgery in Basel we have been involved in the field of micro dialytic monitoring for several years and have recognised the problems, b
出版日期Conference proceedings 1996
关键词brain; care; clinical application; diabetes; dialysis; epilepsy; head; head injury; intensive care; metabolis
版次1
doihttps://doi.org/10.1007/978-3-7091-6894-3
isbn_softcover978-3-7091-7426-5
isbn_ebook978-3-7091-6894-3Series ISSN 0065-1419 Series E-ISSN 2197-8395
issn_series 0065-1419
copyrightSpringer-Verlag/Wien 1996
The information of publication is updating

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Clinical Microdialysis: The Role of On-line Measurement and Quantitative Microdialysis extracellular concentration and the probe recovery in vivo. The clinical applicability of a number of quantitative microdialysis methods is discussed, and three approaches highlighted. By increasing membrane length and reducing flow rate, recovery in vivo can be increased to 100%. In this case dial
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Delayed Neuronal Damage Following Focal Ischemic Injury in Stroke-Prone Spontaneously Hypertensive Rd to the pyramidal tract, thalamus and lateral portion of the striatum by 3 days. A 3-fold increase in glutamate content, and a 2-fold increase in dopamine content were observed only in the lateral part of the striatum following ischemia..The results suggest that excessive release of glutamate and d
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The Measurement of Extracellular Inorganic Phosphate Gives a More Reliable Indication for Severe Imppontaneously recovering event as a SD and a long-lasting or an irreversible loss of cell function as in persisting ischemia/hypoxia. The measurement of IP, therefore, seems to be more suitable than that of lactate or adenosine since IP will appear within the extracellular space only after a sustaine
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A Concept for the Introduction of Cerebral Microdialysis in Neurointensive Carese on-line pH, radical scavengers and uric acid) in the MD set-up must be investigated in vitro and in animal models before use in the clinic. The range of non-pathological values of parameters of interest in human brain should be known. For this purpose we took measurements during an extracranial-i
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Glutamate Release and Cerebral Blood Flow After Severe Human Head Injurydamage was closely related to massive excitatory amino acid release, as in previous animal studies. In patients without secondary ischemia, or focal contusions, delayed post-traumatic glutamate release appeared to be only transient or did not occur at all.
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Microdialytic Monitoring of the Cortex During Neurovascular Surgeryion, or sometimes even before. During the bypass operations, there were no marked changes in on-line pH or in any of the measured parameters. However, in 2 of these patients ascorbic acid, uric acid and glucose levels were very high during the whole measurement, indicating possible changes in metabo
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