Titlebook: Clinical Applications of Cytokines and Growth Factors; John R. Wingard (Professor of Medicine, Director), Book 1999 Springer Science+Busin

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Roy L. Crum,Dan J. Laughhunn,John W. PayneThe association of neutropenia and infection in patients with cancer receiving myelosuppressive chemotherapy was established over three decades ago by Bodey et al, who demonstrated that the risk of infection began to increase as the neutrophil count fell below 1000/mm. and was greatest at levels below 100/mm. (Figure 1).

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Outpatient Management of Neutropenic Fever: Antibiotics, Growth Factors or Both?The association of neutropenia and infection in patients with cancer receiving myelosuppressive chemotherapy was established over three decades ago by Bodey et al, who demonstrated that the risk of infection began to increase as the neutrophil count fell below 1000/mm. and was greatest at levels below 100/mm. (Figure 1).

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Pathophysiology of the Anemia of MalignancyAnemia is common in patients with malignancy and there are many contributors to the anemia, as shown in Table 1. By far and away the most common form of anemia seen in patients with cancer or hematologic malignancies results from the underproduction of red cells - a hypoproliferative anemia.

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Kristen Purcell,Lee Clarke,Linda Renzullirth. A specific stimulus of hypoxia, for example, will result in the expansion of the erythroid bone marrow and subsequent erythrocytosis, but the bone marrow will not increase production of B-lymphocytes or neutrophils. This response evolves from hypoxia-induced increases in circulating levels of e