Titlebook: Circulating Tumor Cells; Richard J. Cote,Ram H. Datar Book 20161st edition Springer Science+Business Media, LLC, part of Springer Nature 2

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Prevention of Conversion of Tumor Dormancy into Proliferative Metastasesprimary tumor. Clinical tumor dormancy thus creates uncertainty for cancer patients and their physicians, who cannot be certain that their cancer will not recur. We have a poor understanding about which individual patients are at risk for cancer recurrence following a period of tumor dormancy. Thus,

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CTC Analysis: FISH, ISH, Array-CGH, and Other Molecular Assaysciated with therapeutic failure and drug resistance, posing considerable clinical challenges to finding effective treatment modalities. Therefore, assessing tumor heterogeneity is clinically important for developing novel and efficient targeted therapy concepts. Molecular analysis of circulating tum

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Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cellshese extremely rare cells. Despite these challenges, there is a pressing need to elucidate the molecular characteristics of these tumor cells. In this chapter, we highlight recent studies on genome-wide gene copy number analysis of CTCs and comparisons with primary tumors. These initial studies serv

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Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor CellsCs in peripheral blood samples has been associated with poor survival outcomes in various cancer types. As a readily accessible source of tumor tissue there is a vast potential to develop CTCs as a biomarker to advance cancer diagnosis, prognosis and the development of novel and targeted therapies.

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Prognostic Implications of CTC in Breast Cancertting of metastatic disease CTC have the potential to reveal important insights into the biology and behavior of the cells undergoing the metastatic process and contributing to the resistance and progression of disease over time. In breast cancer the enumeration of CTC has been demonstrated to be a

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CTCs for Biomarker and Companion Diagnostic Developmento center stage in diagnostic and translational research, largely owing to advances in isolation technology and increasing sensitivity of the various genomic, transcriptomic, and proteomic platforms. As we enter the era of personalized medicine, it is foreseeable that CTCs will become an integral com