Titlebook: Chronic Myeloid Leukemia; Rüdiger Hehlmann Book 20161st edition Springer International Publishing Switzerland 2016 Chronic myeloid leukaem

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CML Blast Crisis: Implications and Management,vention, and early predictors of progression. Also, open questions concerning the cause of clonal evolution, improvement of prevention, identification of patients at risk for progression, and a better pathophysiologic understanding of BC are addressed. Current treatment options are combined in a concluding algorithm for the management of BC.

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Die Struktur reflexiver Erkenntnis, 9;22 translocations as well as cytogenetically cryptic . rearrangements are described. Furthermore, the relevance of additional cytogenetic aberrations in the Ph-positive clone at diagnosis and during the course of the disease is emphasized. Moreover, the impact of the occurrence of Ph-negative clones during follow up is discussed.

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Die Struktur reflexiver Erkenntnis,nalysis and its role in the diagnostic work-up of CML in relation to fluorescence in situ hybridization and RT-PCR-based methods. Standard and variant 9;22 translocations as well as cytogenetically cryptic . rearrangements are described. Furthermore, the relevance of additional cytogenetic aberratio

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Reflexive Erziehungswissenschaftthe discovery of the Philadelphia chromosome. This genomic abnormality is the result of a t(9;22) translocation, which gives origin to a BCR-ABL1 fusion gene. The research focus thereafter shifted to characterising the functional consequence of BCR-ABL1. It was demonstrated that this fusion protein

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Barbara Friebertshäuser Dr. phil.m survival without transformation to blast phase CML has become a reality. However, the majority of patients need to be treated during their entire lifespan; thus, the outcome does not solely depend on treatment efficacy but also on how well therapy is tolerated. TKIs have shown an overall favorable

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