Titlebook: Chemical Synthesis; Gnosis to Prognosis Chryssostomos Chatgilialoglu,Victor Snieckus Book 1996 Kluwer Academic Publishers 1996 Nucleotide.e

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Oligonucleotide-Directed Recognition of Double-Helical DNA,uence-specific artificial nucleases that could cleave long DNA fragments at selected sites, e.g., for mapping genes on chromosomes, iii) to provide a rational basis for the development of new therapeutic agents based on selective modulation of gene expression.

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Synthesis of Giant Modular Structures,, and Whitesides [Harvard University], with Prof. Eschenmoser [ETH Zürich] lurking in the background, will consider an even more complex subject, the synthesis of large objects composed of molecular modules.

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https://doi.org/10.1007/978-3-0348-7075-7to intervene chemically, but we do not know all the rules. In particular we do not understand the balance between structural rigidity leading to pre-organised binding sites, and flexibility which allows the site to recognise and respond to the shape and size of the bound substrate.

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Autobiography

Directed Aromatic Metalation : A Continuing Education in Flatland Chemistry,the synthesis of condensed aromatics; and d) the early stages of the Directed remote Metalation (DreM) tactic and its complementarity to electrophilic substitution. In this manner, the modern view from the flatlands will hopefully be appreciated.

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Cryptanalysis of the Quadratic Generatorted tools such as X-ray crystallography, high field NMR spectroscopy and computer-assisted methods. This article discusses aspects of target-driven synthesis with highlights of research activities in the author’s laboratory over the past ten years.