Titlebook: Cerebral Blood Flow, Metabolism, and Head Trauma; The Pathotrajectory Christian W. Kreipke,Jose A. Rafols Book 2013 Springer Science+Busin

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Unbewiesene Methoden in der Tumortherapie for clinical application of this work has been dampened by a lack of a clinically relevant drug that is specific to ETrA (e.g., Bosentan, a mixed ETrA/B antagonist, causes systemic hypotension and, thus, is not a suitable candidate for improving outcome following TBI). However, in 2007 Actelion dev

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Historical Perspectives in Understanding Traumatic Brain Injury and in Situating Disruption in CBF high prevalence and morbidity of TBI add to the exceeding cost of treating affected patients, which in the USA alone has been estimated to exceed $56 billion annually (Langlois et al., MMWR 52:1–8, 2003). However, despite the seemingly alarming epidemiology of TBI, it has only recently gained signi

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Modeling of Traumatic Brain Injury and its Implications in Studying the Pathology of Repeated Mild role of hypoperfusion, could be achieved with a validated animal model, but most existing models impart acute injuries that are severe and do not simulate the essential characteristics of head impacts that are known to result in mild concussion in humans. Here we discuss several current models of he

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Age and Sex Differences in Cerebral Blood Flow and Autoregulation after Pediatric Traumatic Brain Iury on normal pediatric cerebral physiology and cerebrovascular pathophysiology, such as CO. vasoreactivity and pressure autoregulation, focusing on age and sex differences observed in a bench to bedside translational paradigm. The first half of this chapter discusses the present understanding of ag

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New Frontiers in Clinical Trials Aimed at Improving Outcome Following Traumatic Brain Injury, for clinical application of this work has been dampened by a lack of a clinically relevant drug that is specific to ETrA (e.g., Bosentan, a mixed ETrA/B antagonist, causes systemic hypotension and, thus, is not a suitable candidate for improving outcome following TBI). However, in 2007 Actelion dev

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https://doi.org/10.1007/978-3-662-09072-5penetrating head injury that disrupts normal function of the brain. Though not all head injuries are classified as traumatic, TBI is a major public health problem. It is estimated that 1.7 million people sustain a TBI each year, and of these injuries, 275,000 require hospitalization with 52,000 resu

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Unbewiesene Methoden in der Tumortherapietrauma. Particular focus will be placed on how CBF is regulated in the brain both in normal and pathological situations. Furthermore, the vasodilators and constrictors will be discussed. Finally, this chapter will discuss how CBF influences other pathologies associated with head trauma.

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https://doi.org/10.1007/978-3-662-09074-9njury and constitutes about 80–90 % of all cases. Repetitive mild TBI (rmTBI) has emerged as a significant public health concern as the number of individuals experiencing this type of injury in military combat operations and in athletic endeavors continues to increase at a very high rate. The medica