| 书目名称 | Cellular Peptide Hormone Synthesis and Secretory Pathways |
| 编辑 | Jens F. Rehfeld,Jens R. Bundgaard |
| 视频video | |
| 概述 | illustrates the new endocrine biology, using as examples a broad variety of individual peptide systems.written by experts.first book to extensively cover the topic.Includes supplementary material: |
| 丛书名称 | Results and Problems in Cell Differentiation |
| 图书封面 |  |
| 描述 | The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells. |
| 出版日期 | Book 20101st edition |
| 关键词 | PAC; biosynthesis; cell lines; endocrine biology; endocrinology; genes; granins; prohormone processing; secr |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-11836-4 |
| isbn_softcover | 978-3-642-26276-0 |
| isbn_ebook | 978-3-642-11836-4Series ISSN 0080-1844 Series E-ISSN 1861-0412 |
| issn_series | 0080-1844 |
| copyright | Springer-Verlag Berlin Heidelberg 2010 |
发表于 2025-3-21 19:05:24
