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Titlebook: Cell Penetrating Peptides; Methods and Protocol Ülo Langel Book 2022Latest edition The Editor(s) (if applicable) and The Author(s), under e

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In Silico Design of Chemically Modified Cell-Penetrating Peptidesng drug delivery vehicles. Numerous in silico tools have been developed over the years to design and predict the cell-penetrating peptides that contain natural amino acids. The majority of natural cell-penetrating peptides have several limitations including stability, immunogenicity as well as got e
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A Native CPP from Rattlesnake with Therapeutic and Theranostic Propertiestides can rely on a high content of positive charges, as it is the case of the native CPP crotamine. Crotamine is a polypeptide of about 42 amino acid residues with high content of basic residues as Arg and Lys. Although most of known CPPs are linear peptides, native crotamine from the venom of a So
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Enhancing the Therapeutic Potential of Extracellular Vesicles Using Peptide Technology EVs are able to transfer their contents (including nucleic acids, proteins, lipids, and small molecules) to recipient cells, and thus hold great promise as drug delivery vehicles. However, their therapeutic application is limited by lack of efficient cargo loading strategies, a need to improve EV t
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Membrane Molecular Interactions and Induced Structures of CPPsal properties, they are classified as three main groups, namely hydrophobic, amphipathic, and hydrophilic. They are capable of interacting with the cell membrane without inducing serious toxicity, and they can carry cargo molecules across the membrane. Cargo molecules could be different therapeutics
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