| 书目名称 | Caveolins and Caveolae |
| 副标题 | Roles in Signaling a |
| 编辑 | Jean-François Jasmin,Philippe G. Frank,Michael P. |
| 视频video | http://file.papertrans.cn/223/222676/222676.mp4 |
| 概述 | Discusses pleiotropic functions of caveolae and caveolin proteins.Presents the role and function of caveolae and caveolins in cell signaling and human disease mechanisms.Focuses on selected topics |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm. |
| 出版日期 | Book 2012 |
| 关键词 | Caveolae; Caveolin; Frank; Jasmin; Lisanti; Mechanism; Signaling |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-1222-9 |
| isbn_ebook | 978-1-4614-1222-9Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
|Archiver|手机版|小黑屋|
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