Titlebook: Causation and Disease; A Chronological Jour Alfred S. Evans Book 1993 Springer Science+Business Media New York 1993 AIDS.attention.cancer.c

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Causation and Acute Viral Diseases,tations of the original Henle—Koch postulates. Dr. Thomas Rivers (Figure 3.1), the distinguished American virologist, discussed these issues in his presidential address before the American Society of Immunology in 1937 (Rivers, 1937). Dr. Rivers had headed the virology research program at the Rockef

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Slow and Persistent Viral Infections,Each of them poses problems in meeting the postulates of causation thus far discussed. One type is caused by a unique group of viruses with no detectable immune response. These viruses are called “slow viruses” or “lentiviruses” because of the long period between exposure and the appearance of clini

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Viruses and Cancer,e suspected agent and the development of the disease; (2) the relatively low incidence of most cancers, which makes prospective studies almost impossible because of the large number of persons who must be kept under observation; (3) the possibility that cancer may result as a consequence of a reacti

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Causation of Epidemics and Immunological Diseases,smission of the infectious agent goes back to the work of John Snow and the transmission of cholera; the proof of the microbiological cause of an epidemic became possible in the late 1800s, when methods for isolating bacteria became possible. The methods employed in epidemic investigation for seekin

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,Limitations of the Henle—Koch Postulates,had their limitations. In a subsequent paper on bacteriological research presented at the International Medical Congress in Berlin (see Koch, 1890) he stated that while the bacteria of anthrax, tuberculosis, tetanus, and many animal diseases fully fulfilled his postulates, many others did not. These

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