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Titlebook: Cardiovascular Magnetic Resonance Spectroscopy; Saul Schaefer,Robert S. Balaban (Director) Book 1993 Springer Science+Business Media Dordr

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und the heart, such as the chest wall and diaphragm. In addition, motion of the heart due to cardiac and respiratory motion tends to degrade the signal acquisition. Despite these difficulties, MRS has been used to investigate normal human cardiac metabolism, as well as changes in ischemic heart disease, cardiomyopathies, and transplantation.
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Metabolic Effects of Chemotherapy on the Heart,th adriamycin (ADR; doxorubicin hydrochloride) treatment 4, 6, 7. Furthermore, there are a variety of drugs, including actinomycin D, bleomycin, mithramycin, mitomycin C, and vincristine, that increase the incidence of ADR cardiotoxicity when administered simultaneously or subsequent to ADR therapy 6, 8–11.
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Substrate Metabolism in the Citric Acid Cycle of the Heart by 13C NMR,oyed in some of these classical studies, the first NMR detection in intact cells was not reported until 1972 by the group at Los Alamos 3. Later, observations both in isolated hearts 4 and in vivo 5 were reported.
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Transferring Nucleic Acids to the Gas PhaseThe region of tissue giving rise to the magnetic resonance spectroscopy (MRS) signals must be known, or better yet, controlled, in order to properly interpret the results. This can be a serious issue even in perfused organ studies in situations where the response from a selected region (for instance, a region made ischemic) is desired.
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Magnetic Resonance Spectroscopy: Basic Principles and Potential Applications in the Study of the CaSince its initial demonstration nearly a half century ago 1, 2, nuclear magnetic resonance (NMR) has expanded its domain from a technique in analytical chemistry to a powerful tool in biological research, enabling nondestructive biochemical studies in isolated tissues, perfused organs, intact animals, and humans.
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