Titlebook: Cardiac Glycoside Receptors and Positive Inotropy; Evidence for more th E. Erdmann Conference proceedings 1984 Dr. Dietrich Steinkopff Verl

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Zukunftsfähige Strukturen schaffenCardiac glycoside receptors were defined by simultaneous measurement of .H-ouabain binding and its effects on cardiac cell membranes, contracting cardiac muscle and cultured cardiac cells. These measurements show that:

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Cardiac glycoside binding sites in cultured heart muscle cells,Binding of (.H)-ouabain to cultured cardiac muscle and non muscle cells from chicken embryos and neonatal rats has been characterized and correlated with ouabain-induced inhibition of the sodium pump, as well as with the positive inotropic action of the drug.

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https://doi.org/10.1007/978-3-663-05720-8 the latter 3. would cause an increase of intracellular Ca., which in turn would 4. stimulate the contractile proteins to a larger extent than before addition of the drugs. This hypothesis seemed to explain the increase in force of contraction rather well and also the clinically important arrhythmia

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