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Titlebook: Cancer Therapeutic Targets; John L. Marshall Living reference work 20200th edition Anti-angiogenic Targets.HER2/EGFR Targets.Nuclear Rece

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AR, Overview,Upon reactivation of AR-FL and expression of AR-Vs, traditional methods of treatment targeting the ligand binding domain are ineffective. Targeting the evolutionarily conserved N-terminal domain, DNA binding domain (DBD) or using transcription factors that interact with AR will be key in developing new treatments for PCa.
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B-Raf, cancers. It is believed to be an early event since it is seen in the majority of nevi and a subset of premalignant colon polyps. Several kinase inhibitors targeting B-Raf are approved for advanced melanoma.
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CCL21,. Based on the findings on CCL21, it is anticipated that rational combinations with other treatment modalities will improve the therapeutic efficacy of this chemokine and antitumor benefit in a broad range of solid tumors.
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