Titlebook: Cancer Immunotherapy Meets Oncology; In Honor of Christop Cedrik Michael Britten,Sebastian Kreiter,Hans-Geor Book 2014 Springer Internation

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New Challenges for Macroeconomic Policiestigens as target molecules for acute myeloid leukemia (AML) and applied several distinct approaches to acquire high-affinity TCRs for use in clinical studies. Each antigen and each TCR tells a different story and we have selected several examples to illustrate the hurdles in moving from bench to bed

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https://doi.org/10.1007/978-3-031-62248-9 Safety and good immunogenicity of this novel approach were successfully demonstrated in a phase I/IIa study, and a further development of it is now in clinical phase IIb, proof-of-concept testing. These active immunotherapies can be combined successfully with other immunotherapies such as checkpoin

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https://doi.org/10.1007/978-3-031-62478-0 interest in immunotherapeutic approaches for treatment of RCC. This chapter summarizes the recent developments in the treatment of RCC through immunotherapies approved or in clinical development as well as the immunological role of targeted therapies.

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How T Cells Single Out Tumor Cells: “And That Has Made All the Difference…”

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From Basic Immunology to New Therapies for Cancer Patients agents and by the plasticity of the immune system to select such receptors and to make many copies on demand. Constructing “ein Gedankengebäude” to explain the observations made by Emil von Behring and Shibasaburo Kitasato (1890), he not only created the term “Antikörper” (antibody) to describe suc

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Evolution of the Regulatory Landscape for Immunomodulatory Compounds and Personalized Therapeutic Cay products such as monoclonal antibodies have successfully been developed during the last years and contributed to major advances in cancer therapy. Development of cancer vaccines seemed to be more challenging. Nevertheless, some promising candidates are currently in late-stage clinical development,

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Developing Cancer Immunotherapies as Drugs: Setting the Stage Through Methodological Progressmmunotherapy extends beyond a century with its most noteworthy successes having occurred just in the last 3 years. New drugs in this space – both approved and under investigation – demonstrate increased levels of benefit for patients, and their development is based on progress in basic science and i