| 书目名称 | Cancer Biology and the Nuclear Envelope |
| 副标题 | Recent Advances May |
| 编辑 | Eric C. Schirmer,Jose I. de las Heras |
| 视频video | |
| 概述 | Detailed overview of the wide range of nuclear envelope functions that can and do impact cancer.Timely volume that addresses a re-emerging hot topic, juxtaposing some of the historical and contemporar |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | ."Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues f |
| 出版日期 | Book 2014 |
| 关键词 | DNA; cell cycle regulation; nuclear envelope; signalling; stress response |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4899-8032-8 |
| isbn_softcover | 978-1-4939-5481-0 |
| isbn_ebook | 978-1-4899-8032-8Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 16:35:57
