Titlebook: Cancer; Robert H. Bradbury Book 2007 Springer-Verlag Berlin Heidelberg 2007 Cancer.Chemotherapy.Tumour.angiogenesis.biology.chemistry.medi

磨坊

Joe E. Springer,Patrick H. Kitzmantent analogs of imatinib; (2) non-ATPcompetitive inhibitors of Bcr-Abl; and (3) dual inhibitors of both Bcr-Abl and members of the Src familyof kinases (SFKs) that bind to the active form of Bcr-Abl. The progress made on the development of thesenew agents, including compounds with activity against t

BOGUS

Overview,, the aims of anti-cancerdrug discovery programmes have come more into line with other areas of drug therapy, with emphasis movingmore towards orally bioavailable drugs with pharmacokinetics suitable for dosing once or twice a day,and with a property profile that not only limits toxic effects on pro

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Harass

Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecular Mechanisms, and Progress inture as well as excellent mechanisticwork. Published structure–activity data have revealed an interesting convergence on imidazole pharmacophores.The original hypothesis that drove development of FTIs anticipated therapy targeted specifically at thefarnesylated Ras oncoproteins and cancers with . ge

Defiance

Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2 for Cancer logy of the VEGF family of ligands and receptors and of VEGFR-2 in particular.The attempts to develop effective VEGFR-2 antagonists, including small molecules, antibodies and others,for therapeutic purposes are discussed comprehensively with special emphasis on tumor angiogenesis.

pellagra

Bcr-Abl Kinase Inhibitors,tent analogs of imatinib; (2) non-ATPcompetitive inhibitors of Bcr-Abl; and (3) dual inhibitors of both Bcr-Abl and members of the Src familyof kinases (SFKs) that bind to the active form of Bcr-Abl. The progress made on the development of thesenew agents, including compounds with activity against t

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