Titlebook: Calcium Metabolism, Bone and Metabolic Bone Diseases; Proceedings of the 1 Friedrich Kuhlencordt (Professor of Internal Medic Conference pr

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Studies on the Metabolism, Mode of Action and Pharmacology of Vitamin D and Related Analogsand calcitonin. With each of these regulators, outstanding developments and advances have been made in recent years. It is the purpose of this article to outline some of the developments that have occured, specifically with regard to our understanding of the mechanism of action of vitamin D in terms of its intervention in calcium homeostasis.

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Vitamin D-Dependent Calcium Binding Protein of Rat Renal Cortexity 22 nanomoles Ca bound/mg protein. No renal CaBP was found in kidneys from rachitic rats or in the medulla of normal animals. In contrast with intestinal CaBP, renal CaBP activity does not appear to vary markedly with calcium intake, plasma calcium concentration or urinary calcium excretion.

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https://doi.org/10.1007/978-3-642-76425-7des detailed knowledge of plasma .Ca decay and shows that rhythmicity may be considered as an essential property of the processes involved in calcium metabolism. Moreover, during the modeling, we have attempted to include the new concepts of calcium homeostasis (TALMAGE, 1970; MATTHEWS et al., 1971).

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https://doi.org/10.1007/978-3-662-55426-5convulsant osteomalacia in which the biochemical changes and histological response of the bone to a physiological dose of vitamin D. were measured. In particular osteoid mineralisation as well as bone resorption and formation were quantitated.

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Lebenszyklusorientierte Produktentwicklungigher than 125 nmoles. In order to analyze this action of 25-(OH)-D. further we investigated a possible extrarenal conversion of 25-(OH)-D. into more polar active metabolites. This investigation led to the revelation of a new metabolite termed X., which possesses biological activity.

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K.-H. Schultheis,C. Gebhardt,K. Schwemmleto rule out one of several possible mechanisms. Moreover, a comparison of kinetic studies in man, rat and cow (BRONNER, 1973b) permits the conclusion that similar processes occur in all three species and that these processes are brought out by this type of analysis.

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