Titlebook: Calcium Antagonists; Mechanism of Action Nicholas Sperelakis,James B. Caulfield Book 1984 Martinus Nijhoff Publishing, Boston 1984 calcium

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Evidence for a Modulated Receptor Mechanism of Calcium Channel Blockaded explanations for such phenomena as the selective depression of conduction in ischemic myocardium, suppression of tachycardias, and the selective action of lidocaine on ventricular vs. atrial tissue (4).

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Calcium Antagonistic Agents: Uptake into Various Muscles and their Effects on Calcium Bindingpling of contraction from excitation. Their action can be greatly counteracted by increasing concentration of external calcium. Electrophysiological studies show that the mode of action of these drugs is due to a decrease of transmembrane conductance for calcium ions and, consequently, to a reduction of the slow inward calcium current.

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https://doi.org/10.1007/978-3-642-52615-2 smooth muscle than in cardiac muscle, producing vasodilation at low concentrations and negative inotropy at much higher concentrations. By virtue of this differential effect, some of these calcium antagonists have been found to be useful in the treatment of angina pectoris.

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https://doi.org/10.1007/978-3-642-52615-2y effective in patients with typical exertional angina as well. This paper will review the clinical applications of the calcium blockers in patients with either coronary artery spasm or exertional angina due to occlusive coronary artery disease.

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https://doi.org/10.1007/978-3-662-28386-8ectrogenic influx of calcium occurs during depolarization and has been described by Reuter (11) as a slow inward flow of current and is usually thought to be associated with the plateau of the transmembrane action potential.

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Action of Calcium Slow Channel Inhibitors on Cardiac and Vascular Smooth Muscle Membranes smooth muscle than in cardiac muscle, producing vasodilation at low concentrations and negative inotropy at much higher concentrations. By virtue of this differential effect, some of these calcium antagonists have been found to be useful in the treatment of angina pectoris.

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Antianginal Effects of Calcium Antagonistsy effective in patients with typical exertional angina as well. This paper will review the clinical applications of the calcium blockers in patients with either coronary artery spasm or exertional angina due to occlusive coronary artery disease.

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Effects of Calcium Antagonistic Drugs on Various Heart Tissues, Including Blockade of the Slow Channe drugs, like verapamil, methoxy-verapamil (D600), and nifedipine also block the slow Na. channels of young embryonic chick hearts, these drugs are more accurately described as “slow channel blockers” (Shigenobu et al., 1974; Lee & Tsien, 1983; Kojima & Sperelakis, 1983).

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